Csnk1a1^tm1.1Ybn
Targeted Allele Detail

Summary

• Symbol: Csnk1a1^tm1.1Ybn
• Name: casein kinase 1, alpha 1; targeted mutation 1.1, Yinon Ben-Neriah
• MGI ID: MGI:5543667
• Synonyms: Csnk1a1^fl
• Gene: Csnk1a1 Location: Chr18:61688345-61723132 bp, + strand Genetic Position: Chr18, 34.62 cM, cytoband D3
• Alliance: Csnk1a1^tm1.1Ybn page

Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0 mice show skin hyperpigmentation of ears, paws, mouth, and trunk after tamoxifen treatment

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204886
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neomycin resistance cassette and left exons 1 and 2 floxed. (J:204886)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Csnk1a1^tm1.1Ybn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csnk1a1 Mutation: 38 strains or lines available

References

• Original: J:204886 Elyada E, et al., CKIalpha ablation highlights a critical role for p53 in invasiveness control. Nature. 2011 Feb 17;470(7334):409-13
• All: 11 reference(s)