Csnk1a1^tm1.2Ybn
Targeted Allele Detail

Summary

• Symbol: Csnk1a1^tm1.2Ybn
• Name: casein kinase 1, alpha 1; targeted mutation 1.2, Yinon Ben-Neriah
• MGI ID: MGI:5543668
• Gene: Csnk1a1 Location: Chr18:61688345-61723132 bp, + strand Genetic Position: Chr18, 34.62 cM, cytoband D3
• Alliance: Csnk1a1^tm1.2Ybn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204886
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neomycin resistance cassette and exon 2. (J:204886)

Tumor Data

List all tumor models in MMHCdb carrying Csnk1a1^tm1.2Ybn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csnk1a1 Mutation: 38 strains or lines available

References

• Original: J:204886 Elyada E, et al., CKIalpha ablation highlights a critical role for p53 in invasiveness control. Nature. 2011 Feb 17;470(7334):409-13
• All: 1 reference(s)