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Ehmt1tm2Yshk
Targeted Allele Detail
Summary
Symbol: Ehmt1tm2Yshk
Name: euchromatic histone methyltransferase 1; targeted mutation 2, Yoichi Shinkai
MGI ID: MGI:5543772
Synonyms: GLPCA, GLPflox
Gene: Ehmt1  Location: Chr2:24680781-24809658 bp, - strand  Genetic Position: Chr2, 16.73 cM
Alliance: Ehmt1tm2Yshk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204470
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion, Single point mutation
 
Mutation detailsMost of the reading frame was replaced by a loxP site, cDNA with a nucleotide substitution results in the amino acid substitution of alanine for cysteine at position 1201 (C1201A) in the methyltransferase-dead SET-domain, IRES, neomycin resistance cassette and a loxP site. The mutation abolishes enzymatic activity but does not affect heterodimerization with Ehmt2. (J:204470)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ehmt1 Mutation:  91 strains or lines available
References
Original:  J:204470 Inagawa M, et al., Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech Dev. 2013 Nov-Dec;130(11-12):519-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory