H2-Ab1^b-tm1Wug
Targeted Allele Detail

Summary

• Symbol: H2-Ab1^b-tm1Wug
• Name: histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Gregory F Wu
• MGI ID: MGI:5543894
• Synonyms: H2-Ab1^tm1Wug, IAbeta^bstop^f
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^b-tm1Wug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204951
• Parent Cell Line: LK-1/LK1 (ES Cell)
• Strain of Origin: C57BL/6NHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance/STOP cassette was inserted into intron 1. Flow cytometry confirmed the absence of protein expression in the peripheral blood, spleen and bone marrow. (J:204951)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 83 strains or lines available

References

• Original: J:204951 Archambault AS, et al., Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol. 2013 Jul 15;191(2):545-50
• All: 4 reference(s)