Tg(SNCA*A30P)192Rwm
Transgene Detail

Summary

• Symbol: Tg(SNCA*A30P)192Rwm
• Name: transgene insertion 192, Richard Wade-Martins
• MGI ID: MGI:5543905
• Synonyms: SNCA-A30P
• Transgene: Tg(SNCA*A30P)192Rwm Location: unknown Genetic Position: Chr15, Syntenic
• Alliance: Tg(SNCA*A30P)192Rwm page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SNCA*A30P)192Rwm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: This transgene consists of a 135 kb BAC clone, PAC-27 M07, containing the complete 111 kb human SNCA genomic DNA locus with the Parkinson Disease-associated A30P mutation, flanked by 18 kb of 5' and 6 kb of 3' genomic DNA sequence which includes the promoter. Western blot analysis confirmed expression of the human protein in the brain. Line 192 contains a single copy insertion in chromosome 15. (J:201961)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:201961 Taylor TN, et al., Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P alpha-synuclein BAC transgenic mouse. Neurobiol Dis. 2013 Oct 10;62C:193-207
• All: 2 reference(s)