Xcr1^{tm2(HBEGF/Venus)Ksho}
Targeted Allele Detail

Summary

• Symbol: Xcr1^{tm2(HBEGF/Venus)Ksho}
• Name: chemokine (C motif) receptor 1; targeted mutation 2, Tsuneyasu Kaisho
• MGI ID: MGI:5544058
• Synonyms: Xcr1^DTRvenus
• Gene: Xcr1 Location: Chr9:123681380-123691094 bp, - strand Genetic Position: Chr9, 74.71 cM, cytoband F4
• Alliance: Xcr1^{tm2(HBEGF/Venus)Ksho} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204851
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Xcr1^{tm2(HBEGF/Venus)Ksho} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A fusion of the human HBEGF (DTR; diphtheria toxin receptor) and Venus reporter followed by a loxP and FRT-flanked neomycin resistance cassette replaced the coding sequence. (J:204851)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Xcr1 Mutation: 33 strains or lines available

References

• Original: J:204851 Yamazaki C, et al., Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J Immunol. 2013 Jun 15;190(12):6071-82
• All: 27 reference(s)