Ednrb^tm1.2Nat
Targeted Allele Detail

Summary

• Symbol: Ednrb^tm1.2Nat
• Name: endothelin receptor type B; targeted mutation 1.2, Jeremy Nathans
• MGI ID: MGI:5544085
• Gene: Ednrb Location: Chr14:104052055-104081764 bp, - strand Genetic Position: Chr14, 53.05 cM
• Alliance: Ednrb^tm1.2Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201133
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A LoxP site was inserted upstream of the start codon within the second exon of the targeted gene. A second LoxP site was placed downstream of the second exon, within the second intron. Recombinase mediated recombination removed the selection cassette and exon 2. (J:201133)

Generation of the Ednrb^tm1.1Nat and Ednrb^tm1.2Nat alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ednrb Mutation: 104 strains or lines available

References

• Original: J:201133 Rattner A, et al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
• All: 1 reference(s)