Edn2^tm1.2Nat
Targeted Allele Detail

Summary

• Symbol: Edn2^tm1.2Nat
• Name: endothelin 2; targeted mutation 1.2, Jeremy Nathans
• MGI ID: MGI:5544096
• Gene: Edn2 Location: Chr4:120018403-120024557 bp, + strand Genetic Position: Chr4, 55.77 cM
• Alliance: Edn2^tm1.2Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201133
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The second exon was flanked by two LoxP sites and an FRT flanked neo cassette was inserted. Recombinase mediated recombination removed the selection cassette and exon 2. (J:158269, J:201133)

Generation of the Edn2^tm1.2Nat allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Edn2 Mutation: 14 strains or lines available

References

• Original: J:201133 Rattner A, et al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
• All: 2 reference(s)