Cd44^tm1Stpa
Targeted Allele Detail

Summary

• Symbol: Cd44^tm1Stpa
• Name: CD44 antigen; targeted mutation 1, Steven T Pals
• MGI ID: MGI:5544103
• Synonyms: Cd44^v4-10
• Gene: Cd44 Location: Chr2:102641486-102732010 bp, - strand Genetic Position: Chr2, 54.13 cM
• Alliance: Cd44^tm1Stpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204874
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The targeting construct introduced a partial cDNA encoding constant region 5, splicing variant v4-10 and constant regions 16-20 followed by an IRES, lacZ gene and hygromycin resistance cassette. (J:204874)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd44 Mutation: 72 strains or lines available

References

• Original: J:204874 Zeilstra J, et al., Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. Oncogene. 2014 Jan 30;33(5):665-70
• All: 2 reference(s)