Septin9^tm2.2Emfu
Targeted Allele Detail

Summary

• Symbol: Septin9^tm2.2Emfu
• Name: septin 9; targeted mutation 2.2, Ernst-Martin Fuchtbauer
• MGI ID: MGI:5544191
• Synonyms: Sept9^del
• Gene: Septin9 Location: Chr11:117090487-117253151 bp, + strand Genetic Position: Chr11, 82.61 cM
• Alliance: Septin9^tm2.2Emfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205180
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 2 through 5. (J:205180)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Septin9 Mutation: 200 strains or lines available

References

• Original: J:205180 Fuchtbauer A, et al., Septin9 is involved in septin filament formation and cellular stability. Biol Chem. 2011 Aug;392(8-9):769-77
• All: 1 reference(s)