Pon3^tm1Lus
Targeted Allele Detail

Summary

• Symbol: Pon3^tm1Lus
• Name: paraoxonase 3; targeted mutation 1, Aldons J Lusis
• MGI ID: MGI:5544271
• Gene: Pon3 Location: Chr6:5220852-5256286 bp, - strand Genetic Position: Chr6, 1.99 cM
• Alliance: Pon3^tm1Lus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204799
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: No details provided. Western blot analysis confirmed the absence of protein expression in liver mitochondria. (J:204799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pon3 Mutation: 24 strains or lines available

References

• Original: J:204799 Schweikert EM, et al., PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ. 2012 Sep;19(9):1549-60
• All: 2 reference(s)