Wwtr1^tm1.2Eno
Targeted Allele Detail

Summary

• Symbol: Wwtr1^tm1.2Eno
• Name: WW domain containing transcription regulator 1; targeted mutation 1.2, Eric N Olson
• MGI ID: MGI:5544290
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^tm1.2Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200670
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3. Recombinase mediated recombination removed the neo cassette and exon 3. (J:200670)

Generation of the Wwtr1^tm1.1Eno and Wwtr1^tm1.2Eno alleles

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

References

• Original: J:200670 Xin M, et al., Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44
• All: 5 reference(s)