Tg(Myh6-Yap1*S112A)#Eno
Transgene Detail

Summary

• Symbol: Tg(Myh6-Yap1*S112A)#Eno
• Name: transgene insertion, Eric N Olson
• MGI ID: MGI:5544294
• Synonyms: YapS112A
• Transgene: Tg(Myh6-Yap1*S112A)#Eno Location: unknown
• Alliance: Tg(Myh6-Yap1*S112A)#Eno page

Enhanced cardiac regeneration in Tg(Myh6-Yap1*S112A)#Eno/0 mice

Show the 6 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The alpha myosin heavy chain promoter drives expression of a full length mouse Yap*S112A cDNA with a Flag epitope. The S112A mutation results in a constitutively active nuclear form of the protein. (J:200670)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:200670 Xin M, et al., Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44
• All: 1 reference(s)