Lrrc32^tm1.1Hfuj
Targeted Allele Detail

Summary

• Symbol: Lrrc32^tm1.1Hfuj
• Name: leucine rich repeat containing 32; targeted mutation 1.1, Hodaka Fujii
• MGI ID: MGI:5544317
• Synonyms: GARP^fl
• Gene: Lrrc32 Location: Chr7:98138515-98151038 bp, + strand Genetic Position: Chr7, 53.86 cM, cytoband E1-F2
• Alliance: Lrrc32^tm1.1Hfuj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204761
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. (J:204761)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lrrc32 Mutation: 30 strains or lines available

References

• Original: J:204761 Edwards JP, et al., Regulation of the expression of GARP/latent TGF-beta1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol. 2013 Jun 1;190(11):5506-15
• All: 7 reference(s)