Capn6^tm1Hiso
Targeted Allele Detail

Summary

• Symbol: Capn6^tm1Hiso
• Name: calpain 6; targeted mutation 1, Hiroyuki Sorimachi
• MGI ID: MGI:5544425
• Gene: Capn6 Location: ChrX:142585232-142610408 bp, - strand Genetic Position: ChrX, 64.83 cM, cytoband F2
• Alliance: Capn6^tm1Hiso page

Diameter of tongue muscle fibers is larger in Capn6^tm1Hiso/Capn6^tm1Hiso mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200747
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A lacZ with a nuclear localization signal and flanked by a lox71 and a lox2272 site replaced exon 2 and was followed immediately by an inserted neomycin resistsance cassette. Absence of protein in E10.5 and E12.5 embryos was confirmed by Western blot analysis. (J:200747)

Generation of the Capn6^tm1Hiso allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Capn6 Mutation: 9 strains or lines available

References

• Original: J:200747 Tonami K, et al., Calpain-6 deficiency promotes skeletal muscle development and regeneration. PLoS Genet. 2013 Aug;9(8):e1003668
• All: 2 reference(s)