Pde6b^tm1Eye
Targeted Allele Detail

Summary

• Symbol: Pde6b^tm1Eye
• Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; targeted mutation 1, Stephen H Tsang
• MGI ID: MGI:5544444
• Synonyms: Pde6b^Stop
• Gene: Pde6b Location: Chr5:108536239-108579609 bp, + strand Genetic Position: Chr5, 53.07 cM
• Alliance: Pde6b^tm1Eye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200898
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• A floxed stop cassette was inserted in intron 1 via homologous recombination. (J:200898)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde6b Mutation: 122 strains or lines available

References

• Original: J:200898 Davis RJ, et al., Therapeutic Margins in a Novel Preclinical Model of Retinitis Pigmentosa. J Neurosci. 2013 Aug 14;33(33):13475-13483
• All: 4 reference(s)