Wnk1^tm2.1Juha
Targeted Allele Detail

Summary

• Symbol: Wnk1^tm2.1Juha
• Name: WNK lysine deficient protein kinase 1; targeted mutation 2.1, Juliette Hadchouel
• MGI ID: MGI:5544571
• Synonyms: WNK1^ilox
• Gene: Wnk1 Location: Chr6:119900930-120015633 bp, - strand Genetic Position: Chr6, 56.86 cM
• Alliance: Wnk1^tm2.1Juha page

Increased distal convoluted tubule fractional volume in Wnk1^tm2.1Juha/Wnk1⁺ Tg(Pgk1-cre)1Lni/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site and FRT flanked pgk-neo cassette were inserted 66 bp downstream of exon 1 and an FRT3 flanked pgk-puro cassette and loxP site were inserted 93 bp upstream of exon 2. Flp mediated recombination removed the neo and puro cassettes. (J:200742)

Generation of the Wnk1^tm2.1Juha allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk1 Mutation: 115 strains or lines available

References

• Original: J:200742 Vidal-Petiot E, et al., WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71
• All: 3 reference(s)