Trpv4^tm1.1Ldtk
Targeted Allele Detail

Summary

• Symbol: Trpv4^tm1.1Ldtk
• Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1.1, Wolfgang Liedtke
• MGI ID: MGI:5544606
• Synonyms: Trpv4^lox
• Gene: Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Trpv4^tm1.1Ldtk page

Tamoxifen-treated Trpv4^tm1.1Ldtk/Trpv4^tm1.1Ldtk Tg(KRT14-cre/ERT)20Efu/0 mice show protection from UVB-induced tissue injury

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200749
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 13 and a loxP site and FRT flanked pgk-neo cassette were inserted downstream of exon 13 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:200749)

Generation of the Trpv4^tm1.1Ldtk allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv4 Mutation: 57 strains or lines available

References

• Original: J:200749 Moore C, et al., UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3225-34
• All: 13 reference(s)