Cthrc1^tm1.2Suna
Targeted Allele Detail

Summary

• Symbol: Cthrc1^tm1.2Suna
• Name: collagen triple helix repeat containing 1; targeted mutation 1.1, Sunao Takeshita
• MGI ID: MGI:5544611
• Gene: Cthrc1 Location: Chr15:38940327-38950516 bp, + strand Genetic Position: Chr15, 15.35 cM, cytoband C
• Alliance: Cthrc1^tm1.2Suna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201631
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. A loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 2. RT-PCR confirmed the absence of transcript expression in the bone. (J:201631)

Generation of the Cthrc1^tm1.1Suna and Cthrc1^tm1.2Suna alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cthrc1 Mutation: 34 strains or lines available

References

• Original: J:201631 Takeshita S, et al., Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest. 2013 Sep 3;123(9):3914-24
• All: 1 reference(s)