Gbx1^tm1Mrh
Targeted Allele Detail

Summary

• Symbol: Gbx1^tm1Mrh
• Name: gastrulation brain homeobox 1; targeted mutation 1, Muriel Rhinn
• MGI ID: MGI:5544724
• Gene: Gbx1 Location: Chr5:24709424-24731846 bp, - strand Genetic Position: Chr5, 11.93 cM
• Alliance: Gbx1^tm1Mrh page

Abnormal gait of a Gbx1^tm1Mrh/Gbx1^tm1Mrh mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201154
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A 313 bp region in exon 2 encompassing the entire homeodomain was replaced with a lacZ-neo cassette via homologous recombination. Immunohistochemical analysis confirmed the absence of detectable protein in the spinal cords of homozygous mice at E18.5. (J:201154)

Generation of the Gbx1^tm1Mrh allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbx1 Mutation: 19 strains or lines available

References

• Original: J:201154 Meziane H, et al., The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord. PeerJ. 2013;1:e142
• All: 1 reference(s)