Selenot^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Selenot^tm1.1Ics
• Name: selenoprotein T; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5544732
• Synonyms: SelT^fl
• Gene: Selenot Location: Chr3:58484057-58500554 bp, + strand Genetic Position: Chr3, 28.61 cM, cytoband D
• Alliance: Selenot^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203279
• Parent Cell Line: MCI (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were floxed. Flp-mediated recombination removed an FRT-flanked neomycin resistance cassette. (J:203279)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenot Mutation: 18 strains or lines available

References

• Original: J:203279 Prevost G, et al., The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human beta-cells and its targeted inactivation impairs glucose tolerance. Endocrinology. 2013 Oct;154(10):3796-806
• All: 2 reference(s)