Rps6ka2^tm1.1Mskf
Targeted Allele Detail

Summary

• Symbol: Rps6ka2^tm1.1Mskf
• Name: ribosomal protein S6 kinase, polypeptide 2; targeted mutation 1.1, Michael S Kapiloff
• MGI ID: MGI:5544762
• Synonyms: Rsk3^-
• Gene: Rps6ka2 Location: Chr17:7437514-7570714 bp, + strand Genetic Position: Chr17, 4.7 cM, cytoband F4
• Alliance: Rps6ka2^tm1.1Mskf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette followed by stop codons was inserted into exon 2. Cre-mediated recombination removed the floxed neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the heart. (J:205403)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka2 Mutation: 44 strains or lines available

References

• Original: J:205403 Li J, et al., Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy. Circ Res. 2013 Jan 4;112(1):128-39
• All: 5 reference(s)