Tg(Lrat-cre)1Rshw
Transgene Detail

Summary

• Symbol: Tg(Lrat-cre)1Rshw
• Name: transgene insertion 1, Robert F Schwabe
• MGI ID: MGI:5545650
• Synonyms: LratCre
• Transgene: Tg(Lrat-cre)1Rshw Location: unknown
• Alliance: Tg(Lrat-cre)1Rshw page

Transgene origin

• Strain of Origin: CBA x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Lrat-cre)1Rshw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Lrat

• Mutation details: A construct containing a cassette encoding cre recombinase as well as a neo selection cassette was inserted by recombineering methods into a BAC at the ATG codon of the Lrat locus. The neo was removed by arabinose-induced flippase. Purified BAC DNA was injected into pronuclei of fertilized oocytes. Six founders were positive for the transgene and the line with the strongest cre activity in liver and hemotopoietic stem cells was used for further studies. (J:205330)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lrat (species not specified) Summary of all recombinase alleles driven by Lrat. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:205330 Mederacke I, et al., Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun. 2013;4:2823
• All: 23 reference(s)