Socs7^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Socs7^{tm1c(EUCOMM)Wtsi}
• Name: suppressor of cytokine signaling 7; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5545789
• Synonyms: socs7 fl
• Gene: Socs7 Location: Chr11:97253261-97289368 bp, + strand Genetic Position: Chr11, 60.96 cM
• Alliance: Socs7^{tm1c(EUCOMM)Wtsi} page
• IMPC: Socs7 gene page

Mutation origin

• Mutant Cell Line: EPD0021_4_A12
• Germline Transmission: Earliest citation of germline transmission: J:205551
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt2
• Mutation details: An FRT-flanked cassette with a splice acceptor, lacZ gene, neomycin resistance gene and polyadenylation sequence (en2SA-LacZ-neo-pA) followed by a 3' loxP site was inserted upstream of the second coding exon. An additional loxP site was inserted downstream of the second coding exon. Flp-mediated recombination removed the lacZ/neomycin resistance cassette and left the second coding exon floxed. (J:205551)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs7 Mutation: 22 strains or lines available

Notes

Cell line EPD0021_4_A12 was successfully used to make chimeric mice. Germline transmission was accomplished. J:205551

References

• Original: J:205551 Simo S, et al., Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
• All: 1 reference(s)