Lyn^tm1.1Calo
Targeted Allele Detail

Summary

• Symbol: Lyn^tm1.1Calo
• Name: LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1.1 Clifford A Lowell
• MGI ID: MGI:5545812
• Synonyms: lyn^flox
• Gene: Lyn Location: Chr4:3676865-3791613 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^tm1.1Calo page

Lupus-like autoimmune disease in Lyn^tm1Sor/Lyn^tm1Sor and Lyn^tm1.1Calo/Lyn^tm1.1Calo Top2a^{Gt(PST14568)Mfgc}/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200745
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:200745)

Schematic representation of the gene-targeting construct for obtaining the Lyn^tm1.1Calo allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 65 strains or lines available

References

• Original: J:200745 Lamagna C, et al., Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):E3311-20
• All: 4 reference(s)