Entpd2^tm1Srob
Targeted Allele Detail

Summary

• Symbol: Entpd2^tm1Srob
• Name: ectonucleoside triphosphate diphosphohydrolase 2; targeted mutation 1, Simon C Robson
• MGI ID: MGI:5545886
• Gene: Entpd2 Location: Chr2:25285886-25291333 bp, + strand Genetic Position: Chr2, 17.22 cM
• Alliance: Entpd2^tm1Srob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200972
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette replaced exons 1 and 2 including the promoter region via homologous recombination. RT-PCR analysis confirmed the absence of mRNA in taste buds from homozygous mice. (J:200972)

Generation of the Entpd2^tm1Srob allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Entpd2 Mutation: 25 strains or lines available

References

• Original: J:200972 Vandenbeuch A, et al., Role of the ectonucleotidase NTPDase2 in taste bud function. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14789-94
• All: 3 reference(s)