Wfikkn1^tm1.1Sjl
Targeted Allele Detail

Summary

• Symbol: Wfikkn1^tm1.1Sjl
• Name: WAP, FS, Ig, KU, and NTR-containing protein 1; targeted mutation 1.1, Sejin Lee
• MGI ID: MGI:5546193
• Synonyms: Gasp2^-
• Gene: Wfikkn1 Location: Chr17:26096602-26099832 bp, - strand Genetic Position: Chr17, 12.97 cM
• Alliance: Wfikkn1^tm1.1Sjl page

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201148
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A Lox2272 site was inserted upstream of exon 2 and an FRT flanked neo cassette and Lox2272 site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. (J:201148)

Generation of the Wfikkn1^tm1.1Sjl allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wfikkn1 Mutation: 15 strains or lines available

References

• Original: J:201148 Lee YS, et al., Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
• All: 1 reference(s)