Rgs16^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Rgs16^tm1Sia
• Name: regulator of G-protein signaling 16; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:5546629
• Gene: Rgs16 Location: Chr1:153616099-153621212 bp, + strand Genetic Position: Chr1, 65.43 cM
• Alliance: Rgs16^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205653
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lox71 site, lacZ gene, polyadenylation sequence, FRT-flanked neomycin resistance cassette and loxP site replaced the coding sequence from exon 1 through 5. Western blot analysis confirmed the absence of protein expression in the hypothalamic suprachiasmatic nucleus. (J:205653)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs16 Mutation: 21 strains or lines available

References

• Original: J:205653 Doi M, et al., Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. Nat Commun. 2011;2:327
• All: 1 reference(s)