Plcd1^tm1.1Kfu
Targeted Allele Detail

Summary

• Symbol: Plcd1^tm1.1Kfu
• Name: phospholipase C, delta 1; targeted mutation 1.1, Kiyoko Fukami
• MGI ID: MGI:5546649
• Synonyms: PLCdelta1^fl
• Gene: Plcd1 Location: Chr9:118900595-118922570 bp, - strand Genetic Position: Chr9, 71.32 cM
• Alliance: Plcd1^tm1.1Kfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205633
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neomycin resistance cassette and left exons 4 and 5 floxed. (J:205633)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcd1 Mutation: 44 strains or lines available

References

• Original: J:205633 Kanemaru K, et al., Epidermal phospholipase Cdelta1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun. 2012;3:963
• All: 4 reference(s)