Hsd11b2^tm1.1Mzz
Targeted Allele Detail

Summary

• Symbol: Hsd11b2^tm1.1Mzz
• Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1.1, Ming-Zhi Zhang
• MGI ID: MGI:5547496
• Synonyms: Hsd11b2^flox
• Gene: Hsd11b2 Location: Chr8:106245387-106250620 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Hsd11b2^tm1.1Mzz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neomycin resistance cassette and left exons 1 through 5 floxed. (J:205456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hsd11b2 Mutation: 19 strains or lines available

References

• Original: J:205456 Jiang L, et al., Epithelial-specific deletion of 11beta-HSD2 hinders Apcmin/+ mouse tumorigenesis. Mol Cancer Res. 2013 Sep;11(9):1040-50
• All: 5 reference(s)