Lat^tm9Mal
Targeted Allele Detail

Summary

• Symbol: Lat^tm9Mal
• Name: linker for activation of T cells; targeted mutation 9, Bernard Malissen
• MGI ID: MGI:5547536
• Synonyms: Lat(Y136F)
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^tm9Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205441
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution results in the amino acid substitution of phenylalanine for tyrosine at position 136 (Y136F). (J:205441)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 10 strains or lines available

References

• Original: J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
• All: 1 reference(s)