Prdm4^tm2.1Liz
Targeted Allele Detail

Summary

• Symbol: Prdm4^tm2.1Liz
• Name: PR domain containing 4; targeted mutation 2.1, Elizabeth K Bikoff
• MGI ID: MGI:5547614
• Synonyms: Prdm4^deltazf
• Gene: Prdm4 Location: Chr10:85727828-85752958 bp, - strand Genetic Position: Chr10, 41.75 cM
• Alliance: Prdm4^tm2.1Liz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205013
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 9 through 11, which encode part of the PR/SET domain and zinc fingers 1 through 4. Cre-mediated recombination removed the neomycin resistance cassette. (J:205013)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Prdm4 Mutation: 41 strains or lines available

References

• Original: J:205013 Bogani D, et al., The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo. Mol Cell Biol. 2013 Oct;33(19):3936-50
• All: 1 reference(s)