Nacc1^tm1.1Jlwa
Targeted Allele Detail

Summary

• Symbol: Nacc1^tm1.1Jlwa
• Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; targeted mutation 1.1, Jianlong Wang
• MGI ID: MGI:5547984
• Gene: Nacc1 Location: Chr8:85397106-85414528 bp, - strand Genetic Position: Chr8, 41.02 cM
• Alliance: Nacc1^tm1.1Jlwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203277
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding sequence for the BTB/POZ domain (exon 2). A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neomycin resistance cassette, exon 2 and exon 3. Western blot analysis confirmed the absence of protein expression in chondrocytes. (J:203277)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nacc1 Mutation: 63 strains or lines available

References

• Original: J:203277 Yap KL, et al., Loss of NAC1 expression is associated with defective bony patterning in the murine vertebral axis. PLoS One. 2013;8(7):e69099
• All: 1 reference(s)