Nacc1tm1.1Jlwa
Targeted Allele Detail
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Symbol: |
Nacc1tm1.1Jlwa |
Name: |
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; targeted mutation 1.1, Jianlong Wang |
MGI ID: |
MGI:5547984 |
Gene: |
Nacc1 Location: Chr8:85397106-85414528 bp, - strand Genetic Position: Chr8, 41.02 cM
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Alliance: |
Nacc1tm1.1Jlwa page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of the coding sequence for the BTB/POZ domain (exon 2). A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neomycin resistance cassette, exon 2 and exon 3. Western blot analysis confirmed the absence of protein expression in chondrocytes.
(J:203277)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S1/Sv * C57BL/6 | | | | involves: 129S1/Sv * C57BL/6 | |
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Phenotypes: |
Affected Systems |
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mortality/aging
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preweaning lethality, incomplete penetrance
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reproductive system
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reduced female fertility
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reduced male fertility
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skeleton
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decreased rib number
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abnormal vertebrae morphology
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abnormal thoracic vertebrae morphology
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thoracic vertebral transformation
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abnormal lumbar vertebrae morphology
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lumbar vertebral transformation
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decreased presacral vertebrae number
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sacral vertebral fusion
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√
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abnormal chondrocyte physiology
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√
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nacc1 Mutation: |
63 strains or lines available
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Original: |
J:203277 Yap KL, et al., Loss of NAC1 expression is associated with defective bony patterning in the murine vertebral axis. PLoS One. 2013;8(7):e69099 |
All: |
1 reference(s) |
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