Adgrf5^tm1Shiro
Targeted Allele Detail

Summary

• Symbol: Adgrf5^tm1Shiro
• Name: adhesion G protein-coupled receptor F5; targeted mutation 1, Shigehisa Hirose
• MGI ID: MGI:5547987
• Synonyms: Ig-Hepta^-, Ig-Hepta-null/lacZ
• Gene: Adgrf5 Location: Chr17:43671342-43770448 bp, + strand Genetic Position: Chr17, 19.73 cM
• Alliance: Adgrf5^tm1Shiro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204701
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ with a nuclear localization sequence and neomycin resistance cassette replaced the second exon. Western blot analysis confirmed the absence of protein expression in the lung and kidney. (J:204701)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrf5 Mutation: 74 strains or lines available

References

• Original: J:204701 Fukuzawa T, et al., Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS One. 2013;8(7):e69451
• All: 2 reference(s)