Mapk14^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1.1Lex
• Name: mitogen-activated protein kinase 14; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:5548094
• Synonyms: p38alpha^delta
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119724
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted to flank the first exon, which contains the ATG. Cre-mediated recombination removed the first exon. (J:119724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:119724 Perdiguero E, et al., Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J. 2007 Mar 7;26(5):1245-56
• All: 1 reference(s)