Kmt2a^tm1.1Jjdh
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1.1Jjdh
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1.1, James J Hsieh
• MGI ID: MGI:5548103
• Synonyms: Mll^nc
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1.1Jjdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201612
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: PCR-mediated site-directed mutagenesis replaced Taspase1 cleavage sites 1 and 2 (D/GX to A/AA) to create a non-cleavable product (nc). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon. (J:201612)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:112159 Takeda S, et al., Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression. Genes Dev. 2006 Sep 1;20(17):2397-409
• All: 6 reference(s)