Irak2^tm1.1Pcoh
Targeted Allele Detail

Summary

• Symbol: Irak2^tm1.1Pcoh
• Name: interleukin-1 receptor-associated kinase 2; targeted mutation 1.1, Philip Cohen
• MGI ID: MGI:5548123
• Synonyms: IRAK2[E525A]
• Gene: Irak2 Location: Chr6:113615428-113671987 bp, + strand Genetic Position: Chr6, 52.82 cM
• Alliance: Irak2^tm1.1Pcoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205798
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A GAA to GCA nucleotide substitution results in the amino acid substitution of alanine for glutamic acid at position 525 (E525A). Flp-mediated recombination removed the selection cassettes. The modified exon remains floxed. (J:205798)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irak2 Mutation: 58 strains or lines available

References

• Original: J:205798 Pauls E, et al., Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice. J Immunol. 2013 Sep 1;191(5):2717-30
• All: 1 reference(s)