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Sema4atm3.1Akum
Targeted Allele Detail
Summary
Symbol: Sema4atm3.1Akum
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; targeted mutation 3.1, Atsushi Kumanogoh
MGI ID: MGI:5548203
Synonyms: Sema4AF350C
Gene: Sema4a  Location: Chr3:88343266-88368489 bp, - strand  Genetic Position: Chr3, 38.83 cM
Alliance: Sema4atm3.1Akum page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205754
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 2 and 3 were replaced with a full-length cDNA containing nucleotide substitutions that result in the amino acid substitution of cysteine for phenylalanine at position 350 (F350C) fused to EGFP and followed by a floxed neomycin ressitance cassette. Flp-mediated recombination removed the selection cassette. (J:205754)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sema4a Mutation:  39 strains or lines available
References
Original:  J:205754 Nojima S, et al., A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration. Nat Commun. 2013;4:1406
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory