Sema4atm3.1Akum
Targeted Allele Detail
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Symbol: |
Sema4atm3.1Akum |
Name: |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; targeted mutation 3.1, Atsushi Kumanogoh |
MGI ID: |
MGI:5548203 |
Synonyms: |
Sema4AF350C |
Gene: |
Sema4a Location: Chr3:88343266-88368489 bp, - strand Genetic Position: Chr3, 38.83 cM
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Alliance: |
Sema4atm3.1Akum page
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Germline Transmission: |
Earliest citation of germline transmission:
J:205754
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 2 and 3 were replaced with a full-length cDNA containing nucleotide substitutions that result in the amino acid substitution of cysteine for phenylalanine at position 350 (F350C) fused to EGFP and followed by a floxed neomycin ressitance cassette. Flp-mediated recombination removed the selection cassette.
(J:205754)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sema4a Mutation: |
39 strains or lines available
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Original: |
J:205754 Nojima S, et al., A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration. Nat Commun. 2013;4:1406 |
All: |
2 reference(s) |
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