Coq6^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Coq6^{tm1b(EUCOMM)Hmgu}
• Name: coenzyme Q6 monooxygenase; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5548683
• Gene: Coq6 Location: Chr12:84408530-84420570 bp, + strand Genetic Position: Chr12, 39.18 cM
• Alliance: Coq6^{tm1b(EUCOMM)Hmgu} page
• IMPC: Coq6 gene page

Mutation origin

• Mutant Cell Lines: HEPD0535_5_A07, HEPD0535_5_H05
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Coq6^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Coq6^tm1b(EUCOMM)Hmgu/Coq6^tm1b(EUCOMM)Hmgu	C57BL/6N-Coq6^tm1b(EUCOMM)Hmgu/Ics	HEPD0535_5_A07
hm2	Coq6^tm1b(EUCOMM)Hmgu/Coq6^tm1b(EUCOMM)Hmgu	B6N(Cg)-Coq6^tm1b(EUCOMM)Hmgu/J	HEPD0535_5_H05
ht3	Coq6^tm1b(EUCOMM)Hmgu/Coq6^+	C57BL/6N-Coq6^tm1b(EUCOMM)Hmgu/Ics	HEPD0535_5_A07
ht4	Coq6^tm1b(EUCOMM)Hmgu/Coq6^+	B6N(Cg)-Coq6^tm1b(EUCOMM)Hmgu/J	HEPD0535_5_H05

Phenotypes:

Affected Systems	hm1	hm2		ht3		ht4
show or hide all annotated terms Sex:
Source:	IMPC - ICS	IMPC - JAX	IMPC - JAX	IMPC - ICS	IMPC - ICS	IMPC - JAX
embryo		√	√
embryonic growth retardation		√	√
abnormal embryo size		√
abnormal tail bud morphology		√	√
growth/size/body		√	√
embryonic growth retardation		√	√
abnormal embryo size		√
homeostasis/metabolism					√	√
increased fasting circulating glucose level					√
increased circulating sodium level						√
limbs/digits/tail		√	√
abnormal tail bud morphology		√	√
mortality/aging	√	√	√
embryonic lethality prior to tooth bud stage		√	√
preweaning lethality, complete penetrance	√	√	√
nervous system		√	√
abnormal forebrain development		√	√
vision/eye				√	√
abnormal cornea morphology				√	√
abnormal vitreous body morphology				√
persistence of hyaloid vascular system					√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Coq6 Mutation: 29 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 4 reference(s)