Plk1^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Plk1^{tm1b(EUCOMM)Hmgu}
• Name: polo like kinase 1; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5548960
• Gene: Plk1 Location: Chr7:121758662-121769096 bp, + strand Genetic Position: Chr7, 65.52 cM
• Alliance: Plk1^{tm1b(EUCOMM)Hmgu} page
• IMPC: Plk1 gene page

Mutation origin

• Mutant Cell Line: HEPD0663_7_E04
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Plk1^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Plk1^tm1b(EUCOMM)Hmgu/Plk1^tm1b(EUCOMM)Hmgu	C57BL/6N-Plk1^tm1b(EUCOMM)Hmgu/Tcp	HEPD0663_7_E04

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
Source:	IMPC - TCP
mortality/aging	√
embryonic lethality prior to tooth bud stage	√
embryonic lethality prior to organogenesis	√
preweaning lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plk1 Mutation: 30 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 6 reference(s)