Alkbh4^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Alkbh4^tm1.1Geno
• Name: alkB homolog 4, lysine demethylase; targeted mutation 1.1, Genoway
• MGI ID: MGI:5549955
• Gene: Alkbh4 Location: Chr5:136165000-136170469 bp, + strand Genetic Position: Chr5, 75.82 cM, cytoband G1
• Alliance: Alkbh4^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205739
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette with a 5' loxP site was inserted upstream of exon 2. A loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette, exon 2 and exon 3. (J:205739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh4 Mutation: 7 strains or lines available

References

• Original: J:205739 Li MM, et al., ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. Nat Commun. 2013;4:1832
• All: 1 reference(s)