Atat1^tm1.2Phep
Targeted Allele Detail

Summary

• Symbol: Atat1^tm1.2Phep
• Name: alpha tubulin acetyltransferase 1; targeted mutation 1.2, Paul A Heppenstall
• MGI ID: MGI:5549960
• Gene: Atat1 Location: Chr17:36208487-36220967 bp, - strand Genetic Position: Chr17, 18.75 cM, cytoband B3
• Alliance: Atat1^tm1.2Phep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205737
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 1 through 6. RT-PCR confirmed the absence of transcript expression. (J:205737)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atat1 Mutation: 30 strains or lines available

References

• Original: J:205737 Kalebic N, et al., alphaTAT1 is the major alpha-tubulin acetyltransferase in mice. Nat Commun. 2013;4:1962
• All: 2 reference(s)