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Trp53tm1Manf
Targeted Allele Detail
Summary
Symbol: Trp53tm1Manf
Name: transformation related protein 53; targeted mutation 1, James J Manfredi
MGI ID: MGI:5550149
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm1Manf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT site and a loxP site were inserted in intron 10 and a neomycin resistance cassette followed by a second loxP site was inserted following exon 11. Finally, a second exon 11 with a stop codon in codon 367 (AAG to TAG change) was inserted after the second loxP site. (J:201153)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  240 strains or lines available
References
Original:  J:201153 Hamard PJ, et al., The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 2013 Sep 1;27(17):1868-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory