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Trp53tm1.1Manf
Targeted Allele Detail
Summary
Symbol: Trp53tm1.1Manf
Name: transformation related protein 53; targeted mutation 1.1, James J Manfredi
MGI ID: MGI:5550216
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm1.1Manf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn FRT site and a loxP site were inserted in intron 10 and a neomycin resistance cassette followed by a second loxP site was inserted following exon 11. Finally, a second exon 11 with a stop codon in codon 367 (AAG to TAG change) was inserted after the second loxP site. Excision of the first copy of exon 11 by cre expression results in expression from the second copy of exon 11 which contains a premature stop codon leading to a truncated protein lacking the final 24 amino acids. (J:201153)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 130 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  240 strains or lines available
References
Original:  J:201153 Hamard PJ, et al., The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 2013 Sep 1;27(17):1868-85
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory