Ndfip1^tm1.1Pmo
Targeted Allele Detail

Summary

• Symbol: Ndfip1^tm1.1Pmo
• Name: Nedd4 family interacting protein 1; targeted mutation 1.1, Paula M Oliver
• MGI ID: MGI:5550254
• Gene: Ndfip1 Location: Chr18:38551960-38598250 bp, + strand Genetic Position: Chr18, 20.32 cM, cytoband B3
• Alliance: Ndfip1^tm1.1Pmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205692
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An F3-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed both selection cassettes and left exon 2 floxed. (J:205692)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndfip1 Mutation: 14 strains or lines available

References

• Original: J:205692 Ramos-Hernandez N, et al., Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production. J Immunol. 2013 Aug 15;191(4):1536-46
• All: 5 reference(s)