Atf4^tm1.1Cmad
Targeted Allele Detail

Summary

• Symbol: Atf4^tm1.1Cmad
• Name: activating transcription factor 4; targeted mutation 1.1, Christopher Adams
• MGI ID: MGI:5550363
• Synonyms: ATF4(L), Atf4^lox
• Gene: Atf4 Location: Chr15:80139385-80141742 bp, + strand Genetic Position: Chr15, 37.85 cM
• Alliance: Atf4^tm1.1Cmad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206503
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:206503)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf4 Mutation: 22 strains or lines available

References

• Original: J:206503 Ebert SM, et al., Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy. J Biol Chem. 2012 Aug 10;287(33):27290-301
• All: 25 reference(s)