Rnf31^tm1.1Kiwa
Targeted Allele Detail

Summary

• Symbol: Rnf31^tm1.1Kiwa
• Name: ring finger protein 31; targeted mutation 1.1, Kazuhiro Iwai
• MGI ID: MGI:5550368
• Synonyms: HOIP^FL, Hoip^loxP
• Gene: Rnf31 Location: Chr14:55829199-55841131 bp, + strand Genetic Position: Chr14, 28.19 cM
• Alliance: Rnf31^tm1.1Kiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201885
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 12. An additional loxP site was inserted downstream of exon 18. Flp-mediated recombination removed the selection cassette and left exons 12 through 14 floxed. (J:201885)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Rnf31 Mutation: 50 strains or lines available

References

• Original: J:201885 Sasaki Y, et al., Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells. EMBO J. 2013 Sep 11;32(18):2463-76
• All: 4 reference(s)