Tg(ACTA1-STIM1)2Jmol
Transgene Detail

Summary

• Symbol: Tg(ACTA1-STIM1)2Jmol
• Name: transgene insertion 2, Jeffery Molkentin
• MGI ID: MGI:5550399
• Transgene: Tg(ACTA1-STIM1)2Jmol Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(ACTA1-STIM1)2Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-STIM1)2Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STIM1 (6786)

  Stim1

  (MGI:107476)

• Mutation details: The human STIM1 cDNA encoding the shorter spliced form was cloned into a human ACTA1 promoter (modified with a troponin 1 element to enhance expression in slow fibers) to create a skeletal muscle-specific transgenic strain. Expression is increased approximately 6-fold in the quadriceps, and at uniformly high levels in a broad range of skeletal muscle groups. No expression is observed in the heart. The transgene is integrated on the Y chromosome in this "low expressor" line. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 3 reference(s)