Tg(Ucp1-cre)1Evdr
Transgene Detail

Summary

• Symbol: Tg(Ucp1-cre)1Evdr
• Name: transgene insertion 1, Evan Rosen
• MGI ID: MGI:5550468
• Transgene: Tg(Ucp1-cre)1Evdr Location: unknown
• Alliance: Tg(Ucp1-cre)1Evdr page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ucp1-cre)1Evdr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ucp1 (MGI:98894)

• Mutation details: The C57BL/6 mouse bacterial artificial chromosome (BAC) 148M1 containing the entire Ucp1 gene, and other genes, was modified by inserting sequence encoding cre recombinase, into the translation initiation site into exon 1 of the Ucp1 gene. An FRT site flanked KAN cassette and a loxP site were removed. DNA from the modified BAC clone was used as the source for the transgene, which was microinjected into the pronucleus of FVB fertilized eggs. A founder line was subsequently established. (J:206508, J:214637)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ucp1 (mouse) Summary of all recombinase alleles driven by Ucp1. Comparative matrix view of recombinase activities Alliance mouse Ucp1 gene page

Expression

In Mice Carrying this Mutation:

6 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:214637 Kong X, et al., IRF4 is a key thermogenic transcriptional partner of PGC-1alpha. Cell. 2014 Jul 3;158(1):69-83
• All: 101 reference(s)