Cish^tm1.1Khk
Targeted Allele Detail

Summary

• Symbol: Cish^tm1.1Khk
• Name: cytokine inducible SH2-containing protein; targeted mutation 1.1, Klaus H Kaestner
• MGI ID: MGI:5550527
• Synonyms: Cish^loxP
• Gene: Cish Location: Chr9:107173858-107179983 bp, + strand Genetic Position: Chr9, 57.99 cM
• Alliance: Cish^tm1.1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203844
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked self-excising neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. The final allele lacks the neomycin resistance cassette. (J:203844)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cish Mutation: 23 strains or lines available

References

• Original: J:203844 Jiao Y, et al., CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice. Diabetologia. 2013 Nov;56(11):2435-45
• All: 1 reference(s)